| Acronym | Definition |
|---|
| SSME | Society for the Study of Medical Ethics |
| SSME | Space Shuttle Main Engine |
| SSME | Sustainable Small and Medium Enterprise |
| SSME | Society for the Study of Muslim Ethics (est. 2009) |
| SSME | Sulu-Sulawesi Marine Ecoregion (Malaysia) |
| SSME | Smooth Streaming Media Element (computer application programming interface) |
| SSME | Service Science, Management, Engineering |
| SSME | Siemens Shanghai Medical Equipment Ltd. (China) |
| SSME | Split Symbol Moments Estimator |
| SSME | Spread-Spectrum Modulation Equipment |
