| Acronym | Definition |
|---|
| SPDR | Standard & Poor's Depositary Receipts (pronounced "spider", symbol SPY) |
| SPDR | Serial Peripheral Data Register |
| SPDR | Seattle Purebred Dog Rescue (Seattle, WA) |
| SPDR | System Peril Distributed Reflex (Halo 2, Bungie Game Studios) |
| SPDR | Six-Port Direct Digital Receiver |
| SPDR | Spurious-Free Dynamic Range |
| SPDR | Split Post Dielectric Resonator |
| SPDR | Software Preliminary Design Review |
| SPDR | Subcontractor Preliminary Design Review |
| SPDR | System Performance & Design Requirement |
